Development of online hemodiafiltration in Japan

Abstract Evidence concerning online hemodiafiltration (ol-HDF) includes increased uremic toxin removal, prevention of dialysis-related hypotension, improved survival, and recovery uncertain symptoms. In particular, evidence has been shown regarding dialysis hypotension improvement but the mechanism its manifestation is still unclear effects themselves are questionable. Japan, pre dilution ol-HDF mainly performed, in survival rate on condition convection volume 40 L/session or more. removal ? 1-microglubulin ( MG), which a medium-middle solute, targeted. The antioxidant action (Heme Scavenger) MG, presumed, patients, majority serum deteriorated (oxidized) MG. It pointed out that removing MG by may produce new from liver lead to original effect. However, clinical this desired. Obtaining for indicated activity will advancement HDF.